Chemotherapy has long been a mainstay in cancer treatment, using powerful drugs to kill rapidly dividing cancer cells. Despite its effectiveness, chemotherapy can also damage healthy cells, leading to significant side effects. Recent advancements have focused on optimizing chemotherapy regimens and combining them with other treatments to enhance efficacy and minimize toxicity. Combination therapies, which integrate chemotherapy with immunotherapy, targeted therapy, or radiation, have shown promising results. Additionally, research into biomarkers is helping to identify which patients are most likely to benefit from specific chemotherapy drugs, further personalizing and improving treatment outcomes.